A first genetic portrait of synaptonemal complex variation
نویسندگان
چکیده
منابع مشابه
Synaptonemal Complex Length Variation in Wild-Type Male Mice
Meiosis yields haploid gametes following two successive divisions of a germ cell in the absence of intervening DNA replication. Balanced segregation of homologous chromosomes in Meiosis I is aided by a proteinaceous structure, the synaptonemal complex (SC). The objective of this study was to determine total average autosomal SC lengths in spermatocytes in three commonly used mouse strains (129S...
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Meiosis is a process composed of two divisions of the germ line cells without an intervenient S phase, thus there is no duplication of DNA between the first and the second meiotic divisions. The first meiotic division begins with the pre-leptotene that is the stage where the DNA replicates and chromosomes prepare to enter the meiotic prophase I in most of the organisms with sexual reproduction ...
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The synaptonemal complex (SC) promotes fusion of the homologous chromosomes (synapsis) and crossover recombination events during meiosis. The SC displays an extensive structural conservation between species; however, a few organisms lack SC and execute meiotic process in a SC-independent manner. To clarify the SC function in mammals, we have generated a mutant mouse strain (Sycp1(-/-)Sycp3(-/-)...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2019
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1008337